Table of Contents

Research Methodology

Research Process

  • Each cause is subject to an initial shallow research round of one week of desktop research.
  • If the cause’s estimated cost-effectiveness is at least one magnitude greater than a GiveWell top charity, it passes to the intermediate research round of two weeks of desktop research and expert interviews.
  • Then, if the cause’s estimated cost-effectiveness is still at least one magnitude greater than a GiveWell top charity, it passes to the deep research round of three weeks of desktop research, expert interviews and commissioning of surveys and quantitative modelling.

Evaluative Framework

CEARCH attempts to identify a cause’s marginal expected value (MEV):

  • MEV = t * Σ(n = p * m * s * c)

where

  • t = tractability, or proportion of problem solved per additional unit of resources spent
  • p = probability of benefit/cost
  • m = moral weight of benefit/cost accrued per individual
  • s = scale in terms of number of individuals benefited/harmed at any one point in time
  • c = persistence of the benefits/costs

This can be viewed as an extension of the ITN framework, for this approach also takes into account the three ITN factors:

  • Importance: Factored in with p * m * s * c.
  • Tractability: Factored in with t.
  • Neglectedness: Factored in with (i) c, since the persistence of the benefits will depends on how long the problem would have lasted and harmed people sans intervention, and that in turn is a function of the extent to which the cause is neglected; and (ii) t, since tractability is a function of neglectedness to the extent that diminishing marginal returns apply.

However, the MEV framework has the additional following advantage:

  • Through c, it takes into account of not just the decline (i.e. non-persistence) of a problem from active intervention (i.e. the neglectedness issue), but also decline from secular trends (e.g. economic growth reducing disease burden through better sanitation, nutrition, and greater access to healthcare).

In implementing the MEV framework, especial effort is made to brainstorm for what benefits and costs there are – though, in my experience, the health effects tend to swamp the non-health effects.

For more details, refer to this comprehensive write-up on CEARCH’s evaluative framework (link).

Research Findings

No.CauseMEV
in
DALYs
Cost-
Effectiveness
Relative to
GiveWell
Depth of
Research
1aNuclear War (Abolishment)2480.4Shallow
1bNuclear War (Arsenal Limitation)3,341,6955000Shallow
2Fungal Disease1,1042Shallow
3Asteroids1,3522Shallow
4Hypertension190,927300Shallow
5Access to Mental Health Drugs280.04Shallow
6Tinnitus4500.7Shallow
7Diabetes Mellitus Type 2634,2771000Shallow
8Shigella1920.3Shallow
9Productivity5,5829Shallow
10Coronary Heart Disease18,50330Shallow

Nuclear War (Abolishment)

Taking into account the expected benefits of denuclearization (i.e. fewer deaths and injuries from nuclear war), the expected costs (i.e. more deaths and injuries from conventional war due to weakened deterrence), and the tractability of lobbying for denuclearization, CEARCH finds that the marginal expected value of lobbying for denuclearization to be 248 DALYs per USD 100,000, which is around 40% as cost-effective as giving to a GiveWell top charity.

For more details, refer to our cost-effectiveness analysis (link) on the matter as well as the accompanying research report (link).

Nuclear War (Arsenal Reduction)

Considering the expected benefits of eliminating the risk of nuclear war (i.e. averting nuclear war fatalities, averting nuclear war injuries, and consequently greater economic output), the expected costs (i.e. more conventional war fatalities, more conventional war injuries, and hence decreased economic output), as well as the tractability of lobbying for arsenal limitation, CEARCH finds that the marginal expected value of lobbying for arsenal limitation to mitigate nuclear war to be 3,341,695 DALYs per USD 100,000, which is around 5000x as cost-effective as giving to a GiveWell top charity

For more details, refer to our cost-effectiveness analysis (link) on the matter as well as the accompanying research report (link).

Fungal Disease

Considering the expected benefits of eliminating fungal infections (i.e. fewer deaths, less morbidity and greater economic output) as well as the tractability of vaccine development, CEARCH finds that the marginal expected value of vaccine development for fungal infections to be 1,104 DALYs per USD 100,000, which is around 2x as cost-effective as giving to a GiveWell top charity.

For more details, refer to our cost-effectiveness analysis (link) on the matter as well as the accompanying research report (link).

Asteroids

Factoring in the expected benefits of preventing asteroid impact events (i.e. fewer deaths and injuries) as well as the tractability of lobbying for asteroid defence, CEARCH finds that the marginal expected value of such asteroid defence lobbying to be 1,352 DALYs per USD 100,000, which is around 2x as cost-effective as giving to a GiveWell top charity.

For more details, refer to our cost-effectiveness analysis (link) on the matter as well as the accompanying research report (link).

Hypertension

Taking into account he expected benefits of eliminating hypertension (i.e. improved health and greater economic output), as well as the tractability of sodium taxation policy advocacy, CEARCH finds that the marginal expected value of sodium taxation policy advocacy to control hypertension to be 190,927 DALYs per USD 100,000, which is around 300x as cost-effective as giving to a GiveWell top charity.

For more details, refer to our cost-effectiveness analysis (link) on the matter as well as the accompanying research report (link).

Access to Mental Health Drugs

Considering the expected benefits of greater access to mental health drugs (i.e. improved health from reduced depression and correspondingly greater economic output), the expected costs (i.e. worse health from adverse drug side-effects and correspondingly lower economic output), as well as the tractability of direct delivery (i.e. a charity working to distribute mental health drugs), CEARCH finds that the marginal expected value of distributing mental health drugs to be 28 DALYs per USD 100,000, which is around 4% as cost-effective as giving to a GiveWell top charity.

For more details, refer to our cost-effectiveness analysis (link) on the matter as well as the accompanying research report (link).

Tinnitus

Factoring in the expected benefits of treating tinnitus (i.e. improved health and increased economic output) as well as the tractability of expanding sound therapy as a treatment option, CEARCH finds that the marginal expected value of expanding sound therapy to treat tinnitus to be 450 DALYs per USD 100,000, which is around 70% as cost-effective as giving to a GiveWell top charity.

For more details, refer to our cost-effectiveness analysis (link) on the matter as well as the accompanying research report (link).

Diabetes Mellitus Type 2

Taking into account the expected benefits of eliminating diabetes mellitus type 2 (i.e. improved health and greater economic output), as well as the tractability of policy advocacy for a sugar-sweetened beverages tax, CEARCH finds that the marginal expected value of policy advocacy for a sugar-sweetened beverages tax to eliminate diabetes mellitus type 2 to be 634,277 DALYs per USD 100,000, which is around 1000x as cost-effective as giving to a GiveWell top charity.

For more details, refer to our cost-effectiveness analysis (link) on the matter as well as the accompanying research report (link).

Shigella

Considering the expected benefits of eliminating shigella (i.e. improved health and greater economic output), as well as the tractability of a shigella vaccine advance market commitment (AMC), CEARCH finds that the marginal expected value of a vaccine AMC for shigella to be 192 DALYs per USD 100,000, which is around 30% as cost-effective as giving to a GiveWell top charity.

For more details, refer to our cost-effectiveness analysis (link) on the matter as well as the accompanying research report (link).

Productivity

Factoring in the expected benefits of higher economic productivity (i.e. greater economic output and also improved health), as well as the tractability of educational streaming advocacy, CEARCH finds that the marginal expected value of educational streaming advocacy to boost productivity to be 5,582 DALYs per USD 100,000, which is around 9x as cost-effective as giving to a GiveWell top charity.

For more details, refer to our cost-effectiveness analysis (link) on the matter as well as the accompanying research report (link).

Coronary Heart Disease

Taking into account the expected benefits of eliminating coronary heart disease (i.e. improved health and greater economic output), as well as the tractability of policy advocacy for mandatory trans fat limits, CEARCH finds that the marginal expected value of policy advocacy for such mandatory trans fat limits to eliminate coronary heart disease to be 18,503 DALYs per USD 100,000, which is around 30x as cost-effective as giving to a GiveWell top charity.

For more details, refer to our cost-effectiveness analysis (link) on the matter as well as the accompanying research report (link).